Chloramphenicol
The use of this drug is contraindicated because the use of chloramphenicol will increase the effect of Sildenafil by affecting the patient hepatic and intestinal enzyme metabolism.
Isosorbide dinitrate
The use of this drug is contraindicated because the combination of this drug either increases the effects of the other by vasodilation which leads to fatal hypotension.
Nitroprusside sodium
The use of this drug is contraindicated because the combination of this drug either increases the effects of the others by pharmacodynamic synergism.
Enzalutamide
Use alternative drugs because the use of enzalutamide will decrease the effect of Sildenafil by affecting patient hepatic and intestinal enzyme metabolism.
Acetazolamide
Therapy should be administered with caution because the use of Sildenafil increases the effect of acetazolamide by pharmacodynamic synergism and it also increases the risk of hypotension.
The use of this medicine can lower blood pressure and when combining it with alcohol further increases the effect. You may experience dizziness, lightheadedness, fainting, flushing, headache, and heart palpitation. Also, avoid consuming grapefruit juice because it may increase the effect of avanafil on blood levels.
Cardiovascular disease:
The use of phosphodiesterase-5 enzyme inhibitors is contraindicated in patients with cardiovascular disease. A doctor should consider the vasodilatory effects of this drug and whether they may affect patients with cardiovascular disease. The use of this drug may increase the risk of angina pectoris, AV block, myocardial infarction, ventricular arrhythmia, tachycardia, palpitation, hypotension, postural hypotension, syncope, cerebral thrombosis, cerebrovascular hemorrhage, transient ischemic attack, cardiac arrest, heart failure, and hypertension. These events can occur during or after sexual activity.
Renal dysfunction:
Therapy should be administered with caution in patients with severe renal disease or on renal dialysis. The plasma clearance of this drug is decreased in patients with a severe renal impairment which results in drug accumulation.
Liver diseases:
The use of this drug is not recommended for patients with severe hepatic impairment because the pharmacokinetic disposition of this drug has not been assessed in patients with severe hepatic impairment.
umblr artokineticinThe use of phosphodiesterase-5 enzyme inhibitors is not recommended in patients with severe hepatic impairment because the pharmacodynamic synergism will not affect the effect of phosphodiesterase-5 enzyme inhibitors.
Gastrointestinal diseases:
Therapy should be administered with caution in patients with gastrointestinal diseases or with severe gastrointestinal symptoms. The use of this drug may increase the effect of gastric acid in the patient.
Renal impairment:
Therapy should be administered with caution in patients with renal problems or with renal failure. The use of this drug may increase the effect of metoprolol from its active metabolite. You should discuss the use of this drug with your doctor.
The use of this medicine can reduce the absorption of a mult rebate tablet because thevere care will increase the effect of Sildenafil by blocking the hepatic and intestinal enzyme metabolism.
Drug-Dependent Genes:
The use of phosphodiesterase-5 enzyme inhibitors is not recommended in patients with drug-dependent genes. A drug-dependent phenotype is a syndrome characterized by a higher rate of adverse drug reactions and higher rates of fatal and nonfatal drug reactions. The use of this drug along with alcohol may increase the effect of the drug.
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